Stemodane Diterpenes and Diterpenoids: Isolation, Structure Elucidation, Biogenesis, Biosynthesis, Biological Activity, Biotransformations, Metabolites and Derivatives Biological Activity, Rearrangements

Euphorbia diterpenes: isolation, structure, biological activity, and synthesis (2008-2012).

Nucleoside antibiotics: structure, biological activity, and biosynthesis.

Nucleoside antibiotics are found as diverse groups of secondary metabolites of microbial origin. They include a variety of structural modifications of nucleosides and nucleotides, often leading to intricate molecules. Their biological activities are also wide ranging, including antibacterial, antifungal, antitrypanosomal, antitumor, antiviral, herbicidal, insecticidal, immunostimulating, and of...

Seitomycin: isolation, structure elucidation and biological activity of a new angucycline antibiotic from a terrestrial Streptomycete.

A new antibiotic, named seitomycin (1c), and the known microbial metabolite tetrangulol methyl ether (2) were found in the ethyl acetate extract of two terrestrial Streptomyces sp. isolates. The structure of the new antibiotic was elucidated by spectroscopic studies and by comparison of the NMR data with the structurally related hatomarubigin C (1a) and SM-196 B (1b). Seitomycin (1c) showed mod...

Isolation, Structure elucidation and Biological Activity of Di- (2-ethylhexyl) phthalate Produced by Penicillium janthinellum 62

On the course of screening program for new bioactive compounds, the present study was carried out on the crude extract of Penicillium janthinellum 62. The crude extract of P. janthinellum 62 was fractionated on silica gel column and Sephadex-LH20, ten active fractions were produced. Fraction 7 showed highest antitumor activity, which then purified using preparative TLC and produced six sub-frac...

Isolation and biological activity of new and known isolation and biological activity of new and known diterpenoids from Sideritis stricta Boiss. & Heldr.

Nine known and one new ent-kaurene diterpenoid were isolated from the acetone extract of Sideritis stricta Boiss & Heldr. The new compound, identified as ent-1 beta-hydroxy-7 alpha-acetyl-15 beta,16 beta-epoxykaurane (1) by IR, 1D and 2D NMR techniques and mass spectra, was isolated along with sideroxol (2), 7-acetyl sideroxol (3), 7-epicandicandiol (4), linearol (5), ent-7 alpha,15 beta,18-tri...